Vitamin C

PART 1: How much Liposomal Vitamin C absorbs into a person’s blood (bioavailability)?

While high doses of regular vitamin C powder or capsules will be rejected at high rates from your body, Liposomal Vitamin C is a fantastic alternative.

Figure 1 shows that, compared with “normal” Vitamin C ingestion (single dose of 4 g), ingestion of Liposomal Vitamin C (also 4 g) leads to appreciably greater circulating Vitamin C concentrations.  Hence, liposomes facilitate Vitamin C delivery to the blood.  Having structural analysis and some pictures is nice; however, our interest is in function and achieving the intended goal; with that said, we did include a particle distribution graph at the head of this section.

PART 2: What will Vitamin C do once in the blood (efficacy)?

The next step in the study is to determine if the Vitamin C concentration is meaningful.  In this regard, an ischemia reperfusion study was performed.  Ischemia describes any tissue that has been deprived of blood and oxygen.

Reperfusion occurs when the blood and oxygen supply is returned.  Unfortunately, reperfusion can cause massive oxidative stress on your cardiovascular system, as the oxygen interacts with metabolites produced by the oxygen-deprived tissues.  Per the blue line in the Figure 2, oxidative stress was reduced even during the increased oxidative stress of reperfusion.

PART 3: What is the size of the liposomes using this technology?

Another step in our study is to characterize size ranges for our formulations. 

We have been making Liposomal Vitamin C with a peak particle size of 85 nm (nanometers) and with 92% of the particles being between 60 and 172 nm. 

This tight distribution is indicative of the reproducible and highly controlled manufacturing methodology we’ve invented.

Vitamin D

Abstract

 

The Effect of a Liposomal Cholecalciferol Preparation on 25(OH) Vitamin D Levels – A comparative, open-label study

Fifteen healthy participants underwent baseline 25(OH) Vitamin D testing, followed by supplementation with a liposomal product containing 125 mcg (5,000 IU) vitamin D and 400 mcg vitamin K (as MK7) daily for 30 days.  Participants in this study had an average increase in serum 25(OH) Vitamin D of 73% over baseline. (Fig 1) For comparison, the average increase in 25(OH) Vitamin D with supplementation of a non-liposomal preparation for 30 days at this dosage is 16%.

Individuals who began the study with a 25(OH) Vitamin D level in the “insufficient” range (below 30 ng/mL) had an even greater response, averaging a 112% increase. (Fig 2)

Conclusion: Supplementation with a liposomal vitamin D product for 30 days resulted in a much greater increase in serum 25(OH) Vitamin D than typical results after supplementation with a non-liposomal preparation (avg 73% vs 16%), proving the superior absorption of liposomal Vitamin D.

 

Vitamin B12 (CELLb12®)

Vitamin B12 Study

Abstract

A single-dose, crossover study was conducted in six human subjects of equivalent doses of two dosage forms of vitamin B12 – a standard liposomal liquid and a liposomal powder-filled capsule (using CELLg8® technology). Each subject was given 3 mg of CELLb12® in one dosage form, followed by a washout period of 14 days, then dosing with the other dosage form.

All subjects (with one exception) had an increase above baseline at one or more time points over 135 minutes. Serum B12 increased six-fold on average after taking the CELLb12® liposomal capsule compared to the traditional liposomal liquid when comparing the highest peak of each subject’s serum B12.

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