Folate, also known as vitamin B9, is an essential nutrient that plays a critical role in methylation biochemistry. Folate is required for the methylation cycle, the process by which methyl groups are added to molecules such as DNA, RNA, and proteins, it is a process that affects the expression of genes and can play a role in correct DNA translation.
Folate is required for the formation of S-adenosylmethionine (SAM), which is the main methyl donor in the cell. SAM is used in many methylation reactions, including the methylation of DNA and proteins.
Folate deficiency can lead to disruptions in the methylation cycle, leading to changes in the expression of genes that are involved in critical biochemical steps. Adequate intake of folate is important for maintaining normal DNA methylation and proper gene expression.
References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354546/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879467/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163664/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997693/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354546/
